April 23, 2024Open Access

Datopotamab Deruxtecan in Advanced or Metastatic HR+/HER2– and Triple-Negative Breast Cancer: Results From the Phase I TROPION-PanTumor01 Study

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Abstract

Datopotamab deruxtecan (Dato-DXd) is an antibody-drug conjugate consisting of a humanized antitrophoblast cell-surface antigen 2 (TROP2) monoclonal antibody linked to a potent, exatecan-derived topoisomerase I inhibitor payload via a plasma-stable, selectively cleavable linker.

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Authors

Aditya Bardia

Ian E. Krop

Takahiro Kogawa

Journals

Journal of Clinical Oncology

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Institutions

Harvard University

University of California, Los Angeles

Massachusetts General Hospital

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Datopotamab Deruxtecan in Advanced or Metastatic HR+/HER2– and Triple-Negative Breast Cancer: Results From the Phase I TROPION-PanTumor01 Study

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Abstract

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Discussion

Authors

Journals

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References and Citations

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