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Abstract Triptolide (TPL) is a compound sourced from Tripterygium wilfordii Hook. F., a traditional Chinese medicinal herb recognized for its impressive anti-inflammatory, anti-angiogenic, immunosuppressive, and antitumor qualities. Notwithstanding its favorable attributes, the precise mechanism through which TPL influences tumor cells remains enigmatic. Its toxicity and limited water solubility significantly impede the clinical application of TPL. We offer a comprehensive overview of recent research endeavors aimed at unraveling the antitumor mechanism of TPL in this review. Additionally, we briefly discuss current strategies to effectively manage the challenges associated with TPL in future clinical applications. By compiling this information, we aim to enhance the understanding of the underlying mechanisms involved in TPL and identify potential avenues for further advancement in antitumor therapy.
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Shiwei Bao
Mei Yi
Bo Xiang
Cancer Cell International
Central South University
Xiangya Hospital Central South University
Third Xiangya Hospital
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Bao et al. (Sat,) studied this question.
www.synapsesocial.com/papers/68e6d417b6db6435876517b2 — DOI: https://doi.org/10.1186/s12935-024-03336-y