Targeting cardiomyocyte cell cycle regulation through molecular, epigenetic, and metabolic pathways presents a promising therapeutic strategy for promoting heart regeneration in heart failure.
Stimulating cardiomyocyte proliferation by targeting cell cycle regulation represents a potential therapeutic strategy for heart regeneration in heart failure.
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult heart to regenerate has posed challenges in finding effective treatments for cardiac pathologies. While various medications and surgical interventions have been used to improve cardiac function, they are not able to address the extensive loss of functioning cardiomyocytes that occurs during cardiac injury. As a result, there is growing interest in understanding how the cell cycle is regulated and exploring the potential for stimulating cardiomyocyte proliferation as a means of promoting heart regeneration. This review aims to provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure, while also highlighting established and novel therapeutic strategies targeting this area for treatment purposes.
Zhu et al. (Mon,) conducted a review in Heart failure. Cardiomyocyte cell cycle regulation was evaluated. Targeting cardiomyocyte cell cycle regulation through molecular, epigenetic, and metabolic pathways presents a promising therapeutic strategy for promoting heart regeneration in heart failure.