A Sampling of Highlights from the Literature

What We're Reading| May 02 2024 A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors Author 12 (5): 513. https://doi.org/10.1158/2326-6066.CIR-12-5-WWR Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Single-cell profiling reveals neutrophil complexity in the tumor microenvironment (Mike Haggar via Flickr). The function of neutrophils in the tumor microenvironment is not fully understood, in part because of technical challenges posed by their short half-life that limit single-cell profiling opportunities. Wu et al developed a neutrophil-sorting protocol to enable single-cell RNA-sequencing analysis of matched tumor and normal tissue samples and identified 10 distinct neutrophil clusters. HLA-DR+CD74+ antigen-presenting neutrophils are among the most preferentially enriched in tumors, and metabolomic and epigenetic analyses indicate that leucine-activated neutrophil antigen presentation activates antitumor T cells and enhances the antitumor efficacy of anti–PD-1 in mouse models, highlighting a potential therapeutic opportunity. Wu Y, …, Gao Q. Cell 2024 March 5;187,1422-1439.E24. Macrophages play a role in the beneficial effects of tiragolumab (NIAID via Flickr). Adding the anti-TIGIT tiragolumab to the anti–PD-L1 atezolizumab improved outcomes compared with atezolizumab monotherapy for patients with... You do not currently have access to this content.