A-10 | Percutaneous Coronary Intervention in Patients with Myeloproliferative Neoplasms. A Propensity-Matched Analysis of National Database

Myeloproliferative neoplasms (MPN) are stem cell disorders that include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). MPN are associated with an increased cardiovascular risk including acute coronary syndrome. However, there is a lack of comprehensive data regarding the rate of coronary revascularization, as well as the in-hospital characteristics and outcomes for MPN patients. We aimed to evaluate the temporal trends and outcomes of percutaneous coronary intervention (PCI) among patients with MPN. The National Inpatient Sample database from 2016 to 2019 was queried to identify all PCI hospitalizations. Temporal trends and outcomes of patients with and without MPN following PCI were analyzed. Propensity score matching (PSM) was implemented to compare outcomes between MPN and non-MPN groups. Our study included 1,857,575 PCI hospitalizations with 5,010 (0.27%) patients having MPN. Over the study period, the prevalence of MPN among PCI admissions remained stable (p-value for trend = 0.14). Within the MPN subgroup, ET was the predominant condition (66%), followed by PV (29.7%), and PMF (4.3%), with no significant temporal variation in the distribution of these subtypes. The adjusted odds (aOR) of in-hospital mortality were similar between both groups (aOR:1.14, 95% CI: 0.81-1.59, p=0.458, PSM OR:1.03, 95% CI: 0.64-1.67, p=0.894). MPN patients had a higher odds of major bleeding (aOR:1.59, 95% CI: 1.14-2.20, p=0.006, PSM OR:2.06, 95% CI: 1.21-3.52, p=0.008), need for blood transfusion (aOR:2.45, 95% CI: 1.19-3.13, p<0.001, PSM OR:2.24, 95% CI: 1.52-3.31, p<0.001), and AKI (aOR:1.49, 95% CI:1.26-1.76, p<0.001, PSM OR:1.66, 95% CI: 1.30-2.12, p<0.001). Our study demonstrated that while the prevalence of MPN among patients undergoing PCI remained stable, those with MPN faced higher risks of major bleeding, blood transfusion, and AKI. Further research is warranted to elucidate the underlying reasons for these increased risks.