D-48 | Baseline Anemia and Outcomes in Chronic Total Occlusion Percutaneous Coronary Intervention: A Meta-analysis

Anemia is known to be associated with adverse outcomes in several cardiac procedures. Recent data suggest poorer outcomes in patient with baseline anemia undergoing chronic total occlusion (CTO) percutaneous coronary intervention (PCI). To date, baseline anemia has not been included in risk score predictors for CTO PCI. We conduct a meta-analysis to explore the association between baseline anemia and outcomes in CTO PCI. We conducted a literature search from inception through January 2024 in EMBASE and MEDLINE databases. We included studies that report CTO PCI outcomes in patients with and without baseline anemia. Baseline anemia is defined by hemoglobin level of < 13 g/dL in men and < 12 g/dL in women. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian and Laird to calculate odds ratio (OR), and 95% confidence interval (CI). Two studies were included in the meta-analysis (10,597 patients, including 1,949 patients with anemia (18.4%)). Baseline anemia is associated with increased risk of mortality (OR 2.36, 95% confidence interval (CI) 1.82-3.06, I2 0.0%, p-value 0.00) and increased risk of MACE (OR 1.38, 95% CI 1.06-1.89, I2 35.7%, p-value 0.015). Baseline anemia is associated with increased risk of mortality and MACE following CTO PCI. As anemia is one of the reversible causes, more data is needed to clarify this potential causal relationship to improve CTO PCI outcomes.