How Much Should We Trust Instrumental Variable Estimates in Political Science? Practical Advice Based on 67 Replicated Studies

Abstract Instrumental variable (IV) strategies are widely used in political science to establish causal relationships, but the identifying assumptions required by an IV design are demanding, and assessing their validity remains challenging. In this paper, we replicate 67 articles published in three top political science journals from 2010 to 2022 and identify several concerning patterns. First, researchers often overestimate the strength of their instruments due to non-i.i.d. error structures such as clustering. Second, IV estimates are often highly uncertain, and the commonly used t -test for two-stage-least-squares (2SLS) estimates frequently underestimate the uncertainties. Third, in most replicated studies, 2SLS estimates are significantly larger in magnitude than ordinary-least-squares estimates, and their absolute ratio is inversely related to the strength of the instrument in observational studies—a pattern not observed in experimental ones—suggesting potential violations of unconfoundedness or the exclusion restriction in the former. We provide a checklist and software to help researchers avoid these pitfalls and improve their practice.