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Using hydrophilic matrices offers an intriguing option for the creation of oral sustained-release formulations.They can be used for controlled release of both water-soluble and water-insoluble drugs.The present study explores the potential of linseed mucilage (LM) and fenugreek seed mucilage (FSM) as excipients in drug delivery systems.The main aim of proposed work is to focus on the possibilities of using these polysaccharide in industries with particular reference to its physical properties, chemical properties for the formation of new drug delivery systems.This study aimed to develop and characterize sustained release matrix tablets of Salbutamol Sulphate to treat asthma.Matrix tablets containing Salbutamol Sulphate were prepared using the wet granulation method and subsequently assessed for their drug release profiles.The drug release was decreased with the increase in LM, FSM concentration.Drug release kinetics was explained by Higuchi's equation.Testing of the optimized formulation for stability revealed that the drug degradation was not appreciable.The results suggest that the LM and FSM can be used in the formulation of Sustained release tablets.
Rathi et al. (Mon,) studied this question.