Feasibility of penile erection detection through measurements of light reflection of hemoglobin of the penis

Abstract Timely and accurate diagnosis of erectile dysfunction (ED) is crucial for effective treatment and early detection of health risks. There is a need for a non-invasive sensor for erection detection. This study aims to investigate the feasibility of penile erection detection through measurements of light reflection of hemoglobin (LRH) of the penis. A penile LRH sensor was developed to measure changes in hemoglobin levels of the flaccid and erected penis as a precursor to the development of a SpO2-sensor. Outcomes from penile duplex and LRH measurements in ED patients were compared in the flaccid state as well as during an erection caused by intravenous injection of alprostadil. Results of ten patients getting a full erection are considered. The results show a difference in LRH values during erections measured on the penis compared to a flaccid penis. This is the first human pilot study to demonstrate a higher LRH during the onset of an artificially induced erection in patients with ED, this tendency should be analyzed in larger studies. This is a promising advancement towards the further development of a much-needed non-invasive sensor that has the potential to revolutionize the diagnosis and management of ED.