Efficient pulse sequence design framework for high‐dimensional MR fingerprinting scans using systematic error index

Abstract Purpose For effective optimization of MR fingerprinting (MRF) pulse sequences, estimating and minimizing errors from actual scan conditions are crucial. Although virtual‐scan simulations offer an approximation to these errors, their computational demands become expensive for high‐dimensional MRF frameworks, where interactions between more than two tissue properties are considered. This complexity makes sequence optimization impractical. We introduce a new mathematical model, the systematic error index (SEI), to address the scalability challenges for high‐dimensional MRF sequence design. Methods By eliminating the need to perform dictionary matching, the SEI model approximates quantification errors with low computational costs. The SEI model was validated in comparison with virtual‐scan simulations. The SEI model was further applied to optimize three high‐dimensional MRF sequences that quantify two to four tissue properties. The optimized scans were examined in simulations and healthy subjects. Results The proposed SEI model closely approximated the virtual‐scan simulation outcomes while achieving hundred‐ to thousand‐times acceleration in the computational speed. In both simulation and in vivo experiments, the optimized MRF sequences yield higher measurement accuracy with fewer undersampling artifacts at shorter scan times than the heuristically designed sequences. Conclusion We developed an efficient method for estimating real‐world errors in MRF scans with high computational efficiency. Our results illustrate that the SEI model could approximate errors both qualitatively and quantitatively. We also proved the practicality of the SEI model of optimizing sequences for high‐dimensional MRF frameworks with manageable computational power. The optimized high‐dimensional MRF scans exhibited enhanced robustness against undersampling and system imperfections with faster scan times.