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Abstract ID 96167 Poster Board 483 The escalating global prevalence of inflammatory bowel diseases (IBDs), comprising ulcerative colitis and Crohn's disease, poses a considerable burden on public health. Despite therapeutic advances, persistent inflammation and associated complications underscore the limitations of current medical approaches. Fucoidans, fucose-rich sulfated polysaccharides found in edible brown algae, exhibit promising anti-inflammatory properties. However, variations in bioactivities and efficacy among fucoidans from distinct seaweeds warrant comprehensive investigation. Methods: This study systematically assessed the therapeutic potential of fucoidan extracts from Undaria pinnatifida (UPF) and Fucus vesiculosus (FVF) in a murine model of Dextran Sulfate Sodium (DSS)-induced acute colitis. Daily monitoring of colitis severity, coupled with macroscopic evaluation of collected colons and spleens, provided a comprehensive understanding. Histological scrutiny, utilising Hematoxylin and Eosin (H&E staining), and quantification of cytokines via enzyme-linked immunosorbent assay (ELISA) were integral components of our rigorous methodology Results: Oral administration of UPF and FVF over seven days significantly mitigated body weight loss, improved the Disease Activity Index (DAI), and reduced colon and spleen weight compared to their DSS-treated counterparts. DSS-induced mice exhibited notable histological abnormalities, including loss of crypt architecture, goblet cells, immune cell infiltration, and edema, all of which were effectively reversed by UPF and FVF supplementation. Importantly, the macroscopic improvements correlated with a substantial reduction in the production of 18 pro-inflammatory cytokines in distal colon (DC) tissues. The findings propose the potential of orally administered UPF and FVF as a nutraceutical alternative for IBD treatment This research was funded by Marinova Pty Ltd, Hobart, Australia, grant number 00003944
Ahmad et al. (Mon,) studied this question.