Pulse Explore Journal Club Debates Trending Researchers Journals

Join discussions, follow papers, and never miss your next session.

Download on theApp Store

Home Explore Journal Club Trending

⌘+K

AlphaFold2 structures guide prospective ligand discovery | Synapse

May 16, 2024

View Full Paper

AlphaFold2 structures guide prospective ligand discovery

JLJiankun LyuRockefeller University NKNicholas J. KapolkaUniversity of Miami RGRyan H. GumpperUniversity of North Carolina at Chapel Hill

Key Points

Key points are not available for this paper at this time.

Abstract

AlphaFold2 (AF2) models have had wide impact but mixed success in retrospective ligand recognition. We prospectively docked large libraries against unrefined AF2 models of the σ

Ask AI

Helpful

Bookmark

Share

View Full Paper

Ask AI

Helpful

Bookmark

Share

View Full Paper

Cite This Study

Lyu et al. (Thu,) studied this question.

synapsesocial.com/papers/68e69af9b6db643587620aba https://doi.org/https://doi.org/10.1126/science.adn6354

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Generalized biomolecular modeling and design with RoseTTAFold All-Atom2024 · 893 citations
2Fast and accurate protein structure search with Foldseek2023 · 2,452 citations
3Generic GPCR residue numbers – aligning topology maps while minding the gaps2014 · 509 citations
4Utility of homology models in the drug discovery process2004 · 312 citations
5Automated docking with grid‐based energy evaluation1992 · 947 citations