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Abstract Purpose The prognostic nutritional index (PNI) has been used to assess the immunonutritional status of cancer patients and can predict the prognosis of various solid cancers, and the serum alanine transaminase (ALT)/aspartate transaminase (AST) ratio (LSR) is considered a good predictor of liver injury. So we conduct a retrospective cohort analysis of the relationship between the prognosis of esophageal squamous cell carcinoma (ESCC) patients and LSR or PNI as well as to combine these two indicators (LSR-PNI) for further prognostic analysis in patients with ESCC undergoing radiotherapy (RT). Methods In this study, 134 patients with esophageal cancer were retrospectively analyzed, the Chi-square test was used to compare the count data, univariate and multivariate Cox proportional hazards risk models were used to determine independent risk or prognostic factors. Moreover, we analyzed the combination of the LSR and PNI (LSR-PNI). Results Univariate analysis revealed that T stage, M stage, TNM stage, LSR, and PNI were significant prognostic factors associated with OS. The OS of patients in the low-risk group was better than that of patients in the medium-risk group and the high-risk group (p < 0.0001). Conclusion we found that the prognosis of patients who underwent RT for esophageal cancer was significantly correlated with patient sex, T stage and the PNI. Patients in the low-risk group (high LSR-high PNI) had a longer survival time.
Gao et al. (Fri,) studied this question.
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