Key points are not available for this paper at this time.
Abstract Background Hypoalbuminemia is common in heart failure (HF) patients; however, there are no data regarding the possible long-term prognostic role of serum albumin (SA) in the younger population with chronic HF without malnutrition. The aim of this study was to examine the long-term prognostic role of SA levels in predicting major adverse cardiac events (MACE) in middle-aged outpatients with chronic HF. Methods In the present retrospective analysis, 378 subjects with HF were enrolled. MACE (non-fatal ischemic stroke, non-fatal myocardial infarction, cardiac revascularization or coronary bypass surgery, and cardiovascular death), total mortality, and HF hospitalizations (hHF) occurrence were evaluated during a median follow-up of 6.1 years. Results In all population, 152 patients had a SA value 6.0 mg/dL, chronic kidney disease, and a 10-year age rise, increased the risk of MACE in study participants. Finally, patients with SA < 3.5 g/dl had a higher incidence of hHF ( p < 0.001) and total mortality ( p < 0.001) than patients with SA ≥ 3.5 g/dl. Conclusions Patients with chronic HF that exhibits low SA levels show a higher risk of MACE, hHF and total mortality.
Armentaro et al. (Wed,) studied this question.