Key points are not available for this paper at this time.
Objective: To investigate the association between nighttime blood pressure (BP) measured with home (HBPM) versus ambulatory monitors (ABPM) with indices of preclinical target-organ damage in adolescents and young adults with type 1 diabetes (T1D). Design and method: Individuals aged 12-30 years with T1D underwent 24h ABPM (20-min intervals, Microlife WatchBP O3), home monitoring (duplicate morning and evening measurements for 7 days; 3 measurements/night for 3 nights; Microlife WatchBP Home-N) and assessment of indices of preclinical target-organ damage left ventricular mass index (LVMI), intima-media thickness of common carotid artery and bulb (IMT), albumin-to-creatinine ratio (ACR) in two different morning urine samples. Results: Data from 93 individuals were analyzed (57% males, mean age 21±5.5 years, BMI 24±4 kg/m2, HbA1c 7.2±1.0%, T1D duration 11.2±6.5 years, 24-hour systolic/diastolic ambulatory BP 112±9.3/67±5.6 mmHg, 24h ambulatory hypertension 3.2%). LVMI measurements were available in 79 participants, IMT in 65, and ACR in 88 participants. Nighttime ambulatory and home BP were correlated with LVMI (r=0.35/0.31 for systolic and r=0.26/0.25 for diastolic BP, respectively, p<0.05) and IMT (r=0.34/0.46 for systolic and r=0.29/0.42, for diastolic BP, respectively, p<0.01). ACR was correlated with HbA1c (r=0.24, p<0.05), and inversely with nighttime systolic BP dip in ABPM (r=-0.23, p<0.05). Results of multivariable regression analysis are presented in Table 1. Conclusions: In adolescents and young adults with T1D, nighttime BP measured at home and in ABPM appear to exhibit similar correlations with indices of asymptomatic target-organ damage.
Theodosiadi et al. (Wed,) studied this question.