#3069 The effects of characteristics associated with dialysis on cognitive functions in patients with chronic kidney disease

Abstract Background and Aims Cognitive functions are affected in all stages of chronic kidney disease (CKD), regardless of age. This study aims to determine the effects of characteristics associated with dialysis (peritoneal dialysis (PD) or hemodialysis (HD)) on cognitive functions in patients with CKD. Method CKD patients who were followed up with PD or HD at least for six months from 3 different centers from Turkey were included in this study. For dementia screening, the AD8 dementia scoring system was used. The patients’ sociodemographic characteristics, dialysis types, dialysis access routes, weekly dialysis session numbers, dialysis adequacies, dry weights, and laboratory parameters were recorded. Results A total of 261 CKD patients, 142 of whom were male (54.4%), were included in the study (mean age: 54.46 SD: 15.297, 29.1% over 65 years of age). 151 (57.8%) of the patients were HD patients.HT (70.1%) and DM (28.7%) were the most common comorbidities. While 50% of peritoneal dialysis patients were monitored with APD, 34.4% of HD patients had a central venous catheter (CVC) for vascular access. In the study population there was no statistically significant difference in the prevalence of cognitive impairment between those over and under 65 years of age (65 years of age 61%, 65 years of age 68%, p = 0.300). The prevalence of cognitive impairment was significantly higher in HD patients than in PD patients (p 0.001). PD type was not related with cognitive impairment (p = 0.446). In HD patients under 65 years of age cognitive impairment was observed more frequently in the patients with CVC as vascular access (63% in patients 65 years of age with CVC, 32% in patients with AVF/AVG, p = 0.014). Conclusion Chronic kidney disease is one of the age-independent risk factors for cognitive impairment. In our study group cognitive impairment was similar in different age groups. Compared to HD patients, in PD patients less cognitive impairment was observed. In HD patients under 65 years of age using a CVC as vascular access was associated with more frequent cognitive impairment.