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Background and study aim: None of Serum biomarkers that are utilized for diagnosis and evaluating ulcerative colitis (UC) disease activity is specialized for intestinal inflammation. Thus, it is preferable to have access to simple, low-cost techniques for evaluating disease activity. Aim of the study is to examine whether neutrophil lymphocyte ratio (NLR) levels are changed in UC patients and to know its potential as a simple, affordable, and accessible predictor of ulcerative colitis patients' disease activity. Patients and Methods: This cross-sectional analytic study involved 62 UC patients and 31 volunteers as a control group. All degrees of disease activity and severity were included. Physician global assessment as well as patient's overall Mayo Score. Colonoscopy with a confirmation biopsy and Mayo endoscopic score was calculated. NLR, serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and Fecal calprotectin (FC) were measured in all subjects. Results: NLR was significantly higher in active patients (4.3±2.4) compared to inactive patients (1.7±1.1) and control group (1.8±0.7) with P-value of Conclusion: NLR is strongly correlated with disease activity in patients having UC, and it is more accessible and affordable than many other non-invasive indicators.
Taha et al. (Mon,) studied this question.