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Key Clinical Message Good's syndrome (GS) in conjunction with a severe COVID‐19 infection, shedding light on the complexities of managing this rare condition that combines thymoma and immunodeficiency. Abstract This study delves into the clinical presentation and management of a 63‐year‐old male diagnosed with Good's syndrome (GS) amid a severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. GS, an uncommon association between thymoma and immunodeficiency, remains a clinical mystery, necessitating increased awareness and understanding. Our patient's intricate clinical course, marked by recurrent COVID‐19 symptoms and multiple hospitalizations, exemplifies the challenges posed by GS. Through a systematic review of GS cases globally, we highlight its worldwide distribution, with a substantial proportion reported in Europe. Notably, the diagnosis of thymoma often precedes immunodeficiency, emphasizing the importance of vigilance in clinical assessments.
Tabarsi et al. (Mon,) studied this question.