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Background: Prostate cancer poses a significant health concern in males, exhibiting diverse manifestations ranging from slow to aggressive progression.Diagnostic challenges persist due to limitations of conventional methods like DRE and PSA tests, prompting interest in MRI screening for its enhanced sensitivity and specificity thereby reducing unnecessary biopsy.Methods: This retrospective study, conducted in (Govt Doon Medical College Hospital, a tertiary care centre in Uttarakhand, Northern India, enrolled 100 participants with prostate-specific antigen (PSA) levels above 3 ng/ml.Patients underwent Magnetic resonance imaging (MRI) screening and clinical evaluation, with biopsy confirmation if abnormalities were detected.Primary outcomes assessed prostate cancer incidence over seven years, with secondary outcomes including high-grade disease detection and overall survival.Statistical analyses utilized SPSS 27 for correlations and logistic regression. Results:The study includes 100 prostate cancer cases, categorized into locoregional and advanced prostate cancer groups.Locoregional cases (60 in number, were in the age range of 65-69 yrs, exhibited T3 TNM classification (41.6%) with unknown nodal involvement (66.6%) and absence of distant metastasis (63.3%).Advanced cases (40 in number) shared similar demographics, notably with 82.5% aged 65-69.Comparing MRI and biopsy outcomes, the experimental group detected more cancers (100%) than the reference group (66%).MRI-targeted biopsies showed promise in detecting significant cancers while identifying more clinically insignificant ones. Conclusion:The study demonstrates MRI's potential in detecting prostate cancer, particularly in cases with higher PSA levels or advanced stages.The findings underscore the importance of MRI as a complementary tool in prostate cancer screening, warranting further investigation.
Singh et al. (Wed,) studied this question.