A Sampling of Highlights from the Literature

What We're Reading| June 04 2024 A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors Author 12 (6): 651. https://doi.org/10.1158/2326-6066.CIR-12-6-WWR Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search NK-cell activity is held in check by IGSF8 on tumor cells (from NIAID/NIH via Flickr). It is not clear how MHC class I–deficient tumor cells evade NK cell–mediated killing. Using CRISPR screens, Li et al. find that IGSF8 is highly expressed on tumor cells and suppresses NK-cell function by binding to KIR3DL2 and Klra9 on human and mouse NK cells, respectively. A blocking antibody specific for IGSF8 (IGSF8.06) enhances NK cell–mediated tumor-cell killing in vitro. Use of IGSF8.06, either as a single agent or in combination with anti-PD1, in multiple mouse tumor models shows antitumor activity, with the combination showing an augmented effect, suggesting IGSF8 could potentially provide a new immunotherapeutic target. Li Y, …, Xiao T. Cell 2024 April 23;DOI:10.1016/j.cell.2024.03.039. Hypoxia-TAM destabilize vascular integrity in GBM (from Jensflorian via Wikimedia Commons). Glioblastomas (GBM) are highly infiltrated with monocyte-derived tumor-associated macrophages (Mo-TAMs), which promote tumor progression. Through analysis... You do not currently have access to this content.