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Rhamnus prinoides has an impressive range of medicinal uses with high nutritional value. It is considered a natural product and environmentally friendly material. The objective of the study was to evaluate the in vitro antibacterial and antifungal activities of methanolic and aqueous stem bark and fruit extracts against human bacterial and fungal pathogens. The result showed that the qualitative phytochemical analysis of the stem bark of R. Prinoides revealed the presence of a maximum number of secondary metabolites. UV and FTIR analysis showed the presence of different organic constituents with functional groups of hydroxyl group, C=O, and C-O. The presence of these groups is responsible for the broad spectrum of antimicrobial activities. Antibacterial activity of methanol and aqueous extracts of R. prinoides (stem bark) against B. subtilis, S. aureus, S. pneumoniae, E. coli, S. flexneri, and S. typhi, revealed inhibition zone diameter ranging from 22.17-24.67 mm and 14-28 mm, respectively at 200 µg/ml concentration, compared to a positive control Cipro (25µg) ranged from 22.67-27.80 mm. Similarly, it was reported that the methanol and aqueous extracts of R. prinoides (fruit)showed at the range of 20-22 mm and 10-16, respectively at 200 µg/ml concentration, compared to a positive control Cipro (25µg) ranged from 22.17-24.17 mm. The antifungal activity of methanol and aqueous extracts of R. prinoides (stem bark) against A. flavus and C. Albicans revealed inhibition zone ranging from 14-19 mm and 13-15 mm, respectively at 200 µg/ml concentration, compared to a positive control Nystatin ranged from 18.3-21 mm. antifungal activity of methanol and aqueous extracts of R. prinoides (stem bark) against A. flavus and C. Albicans, revealed inhibition zone ranging from 14-19 mm and 13-15 mm, respectively at 200 µg/ml concentration, compared to a positive control Nystatin ranged from 18.3-21 mm. Therefore, ethanol extract of R. prinoides have the most active antibacterial components than antifungal.
Debalkew et al. (Wed,) studied this question.