Pattern of Liver Enzymes in Type -2 Diabetes Mellitus Subjects with and without Dyslipidemia

Background: Type 2 diabetes mellitus (T2DM) is a major public health concern affecting millions of people worldwide. It is associated with dyslipidemia and disturbed liver function. Pattern of liver enzymes and its association with dyslipidemia in T2DM has been reported in limited studies. Objective: This study was aimed to evaluate the pattern of liver enzymes in T2DM subjects with and without dyslipidemia. Methods: This cross sectional analytical study was conducted in the department of Biochemistry of Sir Salimullah Medical College from March, 2021 to February, 2022. Sampling technique was purposive convenient. According to inclusion and exclusion criteria 100 study subjects were taken in this study, among them 50 T2DM subjects without dyslipidemia were taken as Group A and 50 T2DM subjects with dyslipidemia were taken as Group B. All study subjects were briefed about the study and written consent were taken. After taking informed written consent, their BMI was recorded. Fasting samples were collected from each study subject with full aseptic precaution. Fasting plasma glucose (FPG), glycosylated haemoglobin (HbA1c), fasting lipid profile, and liver enzymes (ALT, AST and GGT) were measured in Group A and Group B. Categorical variables were expressed as frequency and percentage. Continuous variables were expressed as mean ± standard deviation. Unpaired t-test, chi-square test, Fisher’s exact test and pearson’s correlation coefficient test were used for comparison of means and strength of association, where appropriate. All statistical tests were consideded at 5% level of significance. Results: The biochemical parameters FPG, HbA1c, TC, TG, LDL-C, ALT, GGT were significantly higher in Group B compared to Group A. However, mean value of HDL-C was significantly lower in Group B than Group A. Out of 100 subjects overall 6 (12%) subjects in Group A and 47 (94%) subjects in Group B had at least one or more elevated liver enzymes. ALT and GGT had a significant ......