Peiminine ameliorates Crohn’s disease-like colitis by enhancing the function of the intestinal epithelial barrier through Nrf2/HO1 signal

Impaired intestinal barrier function is key in maintaining intestinal inflammation in Crohn's disease (CD). However, no targeted treatment in clinical practice has been developed. Peiminine (Pm) strongly protects the epithelial barrier, the purpose of this study is to investigate whether Pm affects CD-like colitis and potential mechanisms for its action.