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Rationale: Mass spectrometry (MS) is introduced to high school students in the UK in many pre-university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies. This mini‑review describes how we introduce and develop students’ use of MS throughout our three‑year undergraduate spiral curriculum practical program, using atmospheric pressure chemical ionisation MS (APCI/MS). Methods: We have used an Advion Expression spectrometer, fitted with an atmospheric solids analysis probe or a Plate Express TLC sampler for sample introduction. Results: We have successfully demonstrated the use of APCI-MS in a range of practicals and experiments covering organic and organometallic chemistries, with large cohorts of students gaining hands‑on instrumental experience in authentic research settings. Conclusions: APCI-MS has proven to be an easy-to-use and valuable addition to our undergraduate practical course. The robustness of the spectrometer enables routine use by large cohorts of students with minimal supervision, and routine maintenance can be carried out by non-specialist technicians. Students can readily process and interpret results for a series of routine analyses, as well as demonstrate uses in problem-solving exercises.
Worrall et al. (Sun,) studied this question.