Ab1550-HPR Investigation of the Relationship Between Physical Performance Assessments and Biopsychosocial Characteristics of Patient-Reported Outcome Measures in Individuals With Systemic Sclerosis-Pilot Study

Background: Systemic Sclerosis (SSc or scleroderma) is a chronic rheumatic connective tissue disease with skin fibrosis that affects various organs and body systems 1. Considering SSc's heterogeneity, physical and psychosocial involvement, and complexity, there is increasing interest in patient-reported outcome measures (PROMs) 2. On the other hand, physical performance measures (PPMs) focus on measuring what the individual can actually do instead of their perceived capacity 3. Objectives: The study aimed to investigate the relationship between physical performance tests and self-reported biopsychosocial characteristics of individuals with SSc. Methods: The study included 25 individuals with diffuse cutaneous SSc who came for routine follow-up visits in October-December 2023. modified Rodnan skin score (mRSS) and other demographic information were recorded. 6-Minute Walk Test (6MWT), Timed Up and Go (TUG), Stair Climb Test (SCT), Chair Stand Test (CST) as PPMs; Scleroderma Health Assessment Questionnaire (SHAQ), BETY-Biopsychosocial Questionnaire (BETY-BQ), Exercise Self Efficacy Scale (ESES), Short Form 36-physical functioning (SF-36-PF) and Tampa Scale for Kinesiophobia (TSK) were applied as PROMs. Correlation coefficients and significance were determined via the "Spearman" correlation test. Results: The gender of the individuals with SSc was 23 females and 2 males, age 45.64 ± 12.17 years, body mass index 24.83 ± 7.55 kg/m2. PPMs and PROM values of the individuals are shown in Table 1. 6MWT and TUG had moderate and high correlations except for the mRSS value indicating skin involvement, SCT had moderate correlations except for the BETY-BQ which evaluates the biopsychosocial assessment, and TSK which evaluates fear of movement, and CST had moderate correlations except for the mRSS and SHAQ (pTable 1. Characteristics of individuals with SSc Table 2. Correlation coefficients of individuals with SSc Conclusion: In this pilot study, significant relationships were found between patient-reported outcome measures and physical performance tests in individuals with SSc. The fact that the results of these tests measuring physical performance were compatible with the scales frequently used in SSc suggested that these tests could be used to evaluate the performance of individuals with SSc. In particular, the correlation of biopsychosocial characteristics and the functional dimension of quality of life with these performance tests was interpreted as the tests that could be preferred in disease management. It was thought that the efficiency of the study could be increased by increasing the number of individuals. REFERENCES: 1 Denton CP, Khanna D. Systemic sclerosis. The Lancet 2017;390:1685–99. 2 Saketkoo LA, Scholand MB, Lammi MR, Russell AM. Patient-reported outcome measures in systemic sclerosis-related interstitial lung disease for clinical practice and clinical trials. J Scleroderma Relat Disord. 2020;5(2 Suppl):48-60. 3 Bennell K, Dobson F, Hinman R. Measures of Physical Performance Assessments: Self-Paced Walk Test (SPWT), Stair Climb Test (SCT), Six-Minute Walk Test (6MWT), Chair Stand Test (CST), Timed Up 63(11): 350- 370. Acknowledgements: NIL. Disclosure of Interests: None declared.