Pos0872 Analysis of Sarcoid Myocarditis Cohort: Complications and Associated Organ Involvement

Background: Sarcoidosis is a multisystemic disease characterized by noncaseating granulomas. It primarily affects the lungs or thoracic lymph nodes in more than 90 percent of cases. Extrapulmonary sarcoidosis can involve the skin, lymph nodes, eyes, heart, kidneys, muscles, joints, and other organs. Cardiac involvement has been reported in 10-20 percent of sarcoidosis cases and can manifest as asymptomatic or lead to serious complications such as heart failure, conduction disorders, arrhythmias, and sudden death. Objectives: We conducted a study on a large cohort of patients with sarcoid myocarditis, examining potential complications and involvement of other organs. We utilized the TrinetX database, which comprises electronic health records from approximately 80 different global healthcare organizations. Methods: We selected our cohort of patients with sarcoid myocarditis, designating it as the index event. The cohort comprises 8,403 patients using the TrinetX database. We examined the age at the time of diagnosis and the race/ethnicity of patients with sarcoid myocarditis. Additionally, we explored the occurrence of outcomes at any time after the index event. The outcomes of interest included ventricular tachycardia, ventricular fibrillation, cardiac arrest, heart failure, conduction system disorder, sarcoid myositis, sarcoidosis of the lymph nodes, sarcoidosis of the lung, sarcoid meningitis, sarcoid pyelonephritis, sarcoid arthropathy, and sarcoid iridocyclitis. We utilized the International Classification of Diseases, Tenth Revision (ICD-10) codes. Results: The analysis involved 8,403 patients with sarcoid myocarditis (index event). The mean age at the time of the index event was 57.7 years, with a slight male predominance of 54 percent. The racial and ethnic distribution was as follows: white (53%), black or African American (32%), Hispanic (2%), Asian (1%), and unknown or other races (14%). Concerning possible complications of sarcoid myocarditis, ventricular tachycardia occurred in 2,538 patients (31.504% of cases), conduction system disorder in 2,927 cases (36.333% of patients), ventricular fibrillation occurred in 419 (5.201% of patients), heart failure was diagnosed in 4,279 (53.116%), and cardiac arrest reported in 314 (4.233% of patients) (Figure 1). Regarding other organ involvement, cardiac myositis occurred in 100 patients (1.241% of cases of sarcoid myocarditis), sarcoidosis of lymph nodes in 180 patients (2.334% of cases), sarcoidosis of the lung in 2,711 patients (33.652% of cases), sarcoidosis of the skin in 361 patients (4.481% of cases), sarcoid meningitis in 25 patients (0.31% of cases), sarcoid pyelonephritis in 10 patients (0.124% of cases), and sarcoid arthropathy in 84 cases (1.043% of patients), and sarcoid iridocyclitis in 145 (1.8% of patients) (Figure 1). Conclusion: Cardiac involvement should be investigated in all patients with sarcoidosis, given its potential to lead to serious complications. Consideration should also be given to screening for involvement of other organs. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests: None declared.