Ab0113 Sex Differences in Clinical Features and Mortality Rate in Gout: A Nationwide Retrospective Cohort Study

Background: Gout is an inflammatory arthritis that occurs when uric acid crystals crystallize in the joints, frequently linked to elevated levels of uric acid in the body. It is well-known to have a significantly higher incidence rate in men compared to women. Gout patients may have several other coexisting conditions, and these conditions can have an impact on the gout status and mortality. Objectives: Studies on gout in women have been conducted so far; however, there has been a lack of large-scale research in women with gout related to mortality. In this study, we analyzed the sex-based differences in mortality rates among patients with gout in Korea and identified the causes of death. Furthermore, we aimed to analyze the factors contributing to the sex-based differences in the causes of death. Methods: This study based on patients collected from the National Sample Cohort (NHIS-NSC) database. The study included aged 20 or older who were diagnosed as gout and received urate lowering agents (allopurinol, febuxostat, or benzbromarone) at least once. Analysis was performed to find risk factor for mortality and calculate hazard ratio (HR) for overall mortality. Results: The study included 15838 male and 3116 female. No significant difference in mortality was observed between males and females. There was a significant difference observed in age at drug start (Hazard ratio = 1.09, 1.10, respectively). The presence of underlying conditions showed a significant increase in mortality (P Conclusion: The mortality rate was higher in female patients with gout. Difference in mortality rates between male and female patients with gout might be due to differences in age and underlying disease condition rather than sex difference itself. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests: None declared.