Pos0855 Polyautoimmunity and Multiple Autoimmune Syndrome in Systemic Sclerosis

Background: Polyautoimmunity (PA) is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple autoimmune syndrome (MAS). Polyautoimmunity is not well characterized in systemic sclerosis (SSc). Objectives: We aim to describe the prevalence of polyautoimmunity and the multiple autoimmune syndrome in a Spanish cohort of patients with systemic sclerosis. Methods: Observational, analytical and cross-sectional monocenter study. We included 92 patients with diagnosis of SSc according to modified ACR-EULAR 2013 criteria. Demographic, clinical and immunological data were collected. Continuous variables were compared by Student's or Mann Whitney's T test, and categorical variables by Chi2 test or Fisher's exact test. Results: The study population comprised 92 patients with SSc (73% female) with a mean age at inclusion of 65±13.6 years (Table 1). Polyautoimmunity was present in 44 patients (48%) and Multiple autoimmune syndrome was present in 15 patients (16%). The most frequent rheumatics ADs were Sjögren´s syndrome (21/44) and Systemic lupus erythematosus (8/44). The most frequent non-rheumatic ADs were Primary biliary cirrhosis (4/44) and Lichen planus (4/44) (Table 2). Patients with polyautoimmunity had a higher frequency of treatment with antimalarias (p=0.004), and a higher number of positive antibodies (pConclusion: Patients with systemic sclerosis and polyautoimmunity do not have a more aggressive phenotype, however, given the high prevalence of coexisting autoimmune diseases, it is important to diagnose other possible autoimmune diseases in these patients.REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests: None declared.