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An 11-year-old girl presented with focal impaired awareness seizures. MRI brain demonstrated a T2 hyperintense cortical lesion in the left temporal lobe with surrounding vasogenic edema. 18 F-FDG PET/CT was arranged to assess metabolic activity of the cerebral lesion, to screen the whole body for other metabolically active lesions, and to assist biopsy planning. The study demonstrated intensely increased FDG uptake within the left temporal lobe lesion without evidence of hypermetabolic lesions elsewhere on the whole-body acquisition. The brain lesion was excised, and histopathology and molecular testing were consistent with ALK-positive histiocytosis.
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Karan Bir Singh
Kevin London
Jessica Ryan
Clinical Nuclear Medicine
The University of Sydney
Children's Hospital at Westmead
Sydney Children’s Hospitals Network
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Singh et al. (Fri,) studied this question.
www.synapsesocial.com/papers/68e6763ab6db643587600e8a — DOI: https://doi.org/10.1097/rlu.0000000000005302
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