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An efficient and reliable RP-HPLC technique has been developed specifically for the detection and quantification of Nirmatrelvir and its related impurities in pharmaceutical formulations.Waters UPLC Aqcuity system with TUV detector integrated with Empower 2 Software with Agilent C18 column C18 column (5 µm, 4.6 mm X 250 mm) using mobile phase of 0.01N phosphate buffer: Methanol (55:45 v/v) with flow rate 1 ml/min (Detection wavelength 223 nm are the optimised chromatographic conditions for the present study.Degradation studies were performed for Nirmatrelvir drug and its related impurities and the method was validated as per ICH guidelines.
Soujanya et al. (Sat,) studied this question.
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