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Abstract Background Associations between osteoporosis and heart failure or cardiovascular disease have been already reported, however, there are few reports about the association between exercise capacity and bone mineral content (BMC) measured by bioelectrical impedance analysis (BIA) in patients with coronary artery disease (CAD). Purpose In the present study, we aimed to elucidate association between BMC and exercise capacity in CAD patients. Methods We performed cardiopulmonary exercise testing and BIA in total 181 patients (age 63.1±10.7 years old) who admitted to our hospital by CAD. They were treated with medical treatment (n=5), percutaneous coronary intervention (n=134) or coronary artery bypass grafting (n=42). The patients implanted cardiac devices such as pacemaker or implantable cardioverter-defibrillator were excluded. We analyzed the association between BMC measured by BIA and parameters of exercise capacity, laboratory date of blood hemoglobin concentration (Hb), estimated glomerular filtration rate (eGFR), and the parameters of echocardiography (left ventricular ejection fraction, left ventricular dimension, left atrium dimension, E/A). Results BMC showed significant correlation between peak oxygen uptake (peak VO2/W：r=0.312, p＜0.001), peak oxygen pulse (peak VO2/HR：r=0.582, p＜0.001). The parameters of echocardiography showed no significant correlation between BMC. In the laboratory data, Hb showed a significant correlation between BMC (r=0.399, p0.001), whereas eGFR did not. Conclusions The present study demonstrated that BMC showed significant correlations between exercise capacity such as peak VO2/W, peak VO2/HR, and Hb in CAD patients. Both exercise capacity and BMC are strong indicator of prognosis. We also have to take care of bone metabolism in treatment of CAD patients.
Kanazawa et al. (Sat,) studied this question.