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Introduction 0.01 vs STZ+RS), and did not improve significantly in STZ+AMP+RH (482±227, p=NS vs STZ+RH). Similarly, the glucagon response to hypoglycemia demonstrated a blunted response with STZ+AMP+RH (see Figure). Conclusion: The beneficial effects of amitriptyline in restoring the counterregulatory response to hypoglycemia that were initially observed in nondiabetic model seem to be attenuated in the insulin deficient diabetic rodent model. It is concluded that chronic diabetes abrogates the beneficial effects of serotonin and norepinephrine reuptake inhibitors on the sympathoadrenal and counterregulatory responses to hypoglycemia. Disclosure M.B. Music: None. A. Thompson: None. A. Iles: None. A.R. Marksbury: None. B. Patel: None. L.A. Schoeder: None. M. Wooten: None. Z. Beckner: None. M.H. Devore: None. E.L. Macon: None. S.J. Fisher: None.
MUSIC et al. (Fri,) studied this question.