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Introduction 0.0001 vs STZ+RS) and then reduced in STZ+RH+MET (24±0.1 mg/kg/min, p0.05 vs STZ+RH). The glucagon response to hypoglycemia in control STZ+RS (p0.05 vs basal) was abrogated in STZ+RH (p=NS vs basal) and restored in STZ+RH+MET (p0.05 vs basal). Conclusions: In this model of insulin deficient diabetes, the detrimental effect of recurrent hypoglycemia on glucoregulatory and counterregulatory hormonal response to hypoglycemia was reversed with metoclopramide treatment. It is concluded that the impaired response to hypoglycemia may be regulated via dopaminergic signaling. Disclosure M.H. Devore: None. A. Iles: None. L.A. Schoeder: None. M.B. Music: None. B. Patel: None. A.R. Marksbury: None. M. Wooten: None. A. Thompson: None. Z. Beckner: None. E.L. Macon: None. S.J. Fisher: None. Funding R01DK1180825T32DK0913171R25DK1098941T32DK110966
DEVORE et al. (Fri,) studied this question.