1331-P: High Pancreatic Steatosis Prevalence in Type 2 Diabetes Mellitus—What Are the Potential Associated Factors?

Introduction and Objectives: T2DM is linked to ectopic fat storage. Data on pancreatic steatosis (PS) and its associated factors in T2DM are scarce. This study aims to determine PS prevalence in T2DM population and to assess clinical, laboratory or body composition associated factors. Methods: Adults over 18 years attending the outpatient T2DM clinic were included in this cross-sectional study. Clinical, biochemical, anthropometric and body composition data were collected. PS and stiffness were evaluated by ultrasound and elastography (shear wave 2D). Data were analyzed with x2 and student t test. Results: Out of 664 reviewed medical records, 204 individuals met the inclusion criteria and consented to participate. So far, 86 individuals have been evaluated and PS evaluation was possible in 83 (96%), being present in 78 94%; mild n = 33 (38%); moderate n = 43 (50%) and severe n = 2 (2%). As the majority exhibited some PS degree, we compared subjects with no/mild vs. moderate/severe PS (Table 1). Waist circumference (WC) was the only variable associated with greater PS. Pancreatic stiffness evaluation was possible in 44 (53%) participants (median = 7 kPa), being similar in both groups. Conclusion: PS evaluation by ultrasound is feasible and highly prevalent in the T2DM population. WC was the only variable associated with PS. Pancreatic stiffness evaluation was possible in half of the sample and was not associated with PS. Disclosure P. de Almeida: None. G.T. Pulz: None. M.K. Jung: None. V. Copatti: None. G.R. Muller: None. M.G. Friedrich: None. R.S. De Fraga: None. C.S. Faccin: None. C.B. Leitao: None.