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Stroke and traumatic brain injury (TBI) are leading causes of morbidity and mortality, affecting survivors' mobility and social participation. Although personalized interventions could positively impact survivors' recovery, the effectiveness of such interventions remains unclear. Open-access data repositories can provide access to multiple shared data which could help uncover new evidence of effective interventions; however, harmonizing data between different studies requires many steps to make it possible given the various methods of data collection, intervention characteristics and population sociodemographic profile. This proof-of-concept study aimed to describe the steps and anchors that contributed to the development of guiding frameworks to harmonize data across different studies. Data were extracted from the Federal Interagency Traumatic Brain Injury Research (FITBIR) repository and stored on an online cloud platform. The outcome measures were mapped to mobility determinants using the International Classification of Functioning, Disability, and Health (ICF) and Webber framework. The intervention's effect was categorized according to the Minimal Clinically Important Difference (MCID)s of the measures administered. The study proposed a novel framework for intervention features, which aims to enhance our understanding of the mechanisms of action and potential impact of rehabilitation interventions. The framework classified interventions based on their nature, context, specific body systems, dosage, caregiver assistance, and behaviour change strategies. In conclusion, this study demonstrated the feasibility of harmonizing data extracted from different sources in the FITBIR repository. Leveraging existing open databases offers tremendous opportunities to advance research on personalized interventions for patients with TBI and stroke and inform decision-making during transitions.
Allegue et al. (Wed,) studied this question.