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Background: Artemisinin-resistant parasites pose a danger to the efficacy of malaria treatment. For a very long time, pharmaceutical companies have relied on plants to provide the prototype molecules required to cure Plasmodium infections. Objective: To evaluate the haematological effects and anti-plasmodial efficacy of combined extracts of Toddalia asiatica and Carica papaya in mice infected with Plasmodium berghei. Methods: 30 mice were divided into 6 groups of 5 mice each. Each experimental mouse received an intraperitoneal injection of an infected blood containing 1x106 red blood cells parasitized by Plasmodium berghei, followed by daily administration of the plant extracts. Group 1-3 received 500,250 and 100 mg/kg of the plant extracts respectively. Group 4 received 500mg/kg of a combination of the two plants extracts. Finally group 5 were give distilled water while group 6 was treated with chloroquine for four consecutive days. For toxicity test the animals received 500mg/kg of the plant extracts combination for14 consecutive days. Results: At day three following infection, the data demonstrated a significant (p 0.05), suggesting that the combination is a reasonably safe treatment for malaria.
Omondi et al. (Thu,) studied this question.