Salivary Biomarkers in Oral Cancer Screening

Oral squamous cell carcinoma (OSCC) is among the most common cancers worldwide.Late diagnosis precludes to poor prognosis.A major barrier in early detection of cancer is the lack of early detection protocols.This has warranted the need for novel methods of cancer detection.The non-invasiveness and ease of handling saliva as a diagnostic tool can be considered as a useful adjuvant in oral cancer detection.The analysis of salivary biomarkers (proteomics, genomics, & metabolomics) will be a promising tool in early detection and management of OSCC.This literature review aims to categorize the various salivary biomarkers that have been identified in oral squamous cell carcinoma.A PubMed literature search was conducted and relevant articles were reviewed.