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Hereditary nonpolyposis colorectal cancer, or Lynch syndrome, is an autosomal dominant cancer predisposition syndrome caused by pathogenic germline variants in DNA mismatch repair genes (mutL homolog 1, mutS homolog 2, mutS homolog 6, PMS1 homolog 2 PMS2) or deletions in epithelial cell adhesion molecule.1,2 Lynch syndrome is most clearly associated with increased risk of colorectal and endometrial cancers, as well as skin cancers including sebaceous neoplasms and keratoacanthoma-type squamous cell carcinoma.
Kuo et al. (Fri,) studied this question.
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