Association of Serum Magnesium Levels and Dyslipidemia in Patients of Type 2 Diabetes Mellitus

BACKGROUND:Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia resulting from resistance to insulin and decreased insulin secretion by the beta cells of the pancreas. Intracellular magnesium is required as co-factor for many enzymes involved in lipid metabolism. Magnesium deficiency has been found to have a role in the disruption of lipid metabolism in patients of type 2 diabetes mellitus. MATERIALS AND METHODS:This hospital based observational cross-sectional study was done between July 2021 and June,2022. 160 cases of Type 2 DM attending the Department ofMedicine, Assam Medical College & Hospital, Dibrugarh were enrolled for the study, as per inclusion and exclusion criteria. RESULTS: Mean age was 52.59±7.13 years. Mean HbA1c was 10.02 ±1.83 %. Mean serum magnesium level was 1.54±0.42 mg/dl. Mean serum triglyceride was 267.27±89.13 mg/dl, mean total cholesterol was 271.65±65.18 mg/dl, mean LDLc was 143.31±15.07 mg/dl and mean HDLc was 39.86±10.55 mg/dl. There was a statistically significant negative correlation between serum magnesium and LDLc (r= -0.906), serum magnesium and Triglycerides, (r= -0.995) and serum magnesium and Cholesterol levels (r=-0.991) and a statistically significant positive correlation between serum magnesium and HDLc r=+0.596). CONCLUSION: Low serum magnesium levels in diabetics correlate with dyslipidemia in Type 2 DM patients. Further studies are required to clinically investigate the role of magnesium in helping prevent dyslipidemia and complications among Type 2 DM patients.