Key points are not available for this paper at this time.
Objective To compare immunological responses of preterm infants to a four-component meningococcal B vaccine (4CMenB; Bexsero) following a 2+1 vs a 3+1 schedule, and to describe reactogenicity of routine vaccines. Design An open-label, phase IV randomised study conducted across six UK sites. Setting Neonatal units, postnatal wards, community recruitment following discharge. Participants 129 preterm infants born at a gestation of 38.0°C than those in the 2+1 group who did not (group 2+1: 2% (n=1); 3+1: 14% (n=9); p=0.02). Conclusions Both schedules were immunogenic in preterm infants, although a lower response against strain NZ98/254 was seen in the 2+1 schedule; ongoing disease surveillance is important in understanding the clinical significance of this difference. Trial registration number NCT03125616 .
Calvert et al. (Mon,) studied this question.