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Pig translational model in immunological researchThe pig is, due to its similarity to humans in anatomy, physiology, and genetics, a frequently used translational animal model in biomedical research (1).Closed composition of human and pig microbiomes (2, 3) predestine the pig to microbiota-host interference studies.Histological differences in human hemochorial and pig epitheliochorial placentas (4) allow modulation of immunocompetence in newborn piglets reared in microbiologically controlled (gnotobiotic) conditions (5).Piglets are born without the mother's protective antibodies that would prevent them from developing sepsis when they are colonized with myriads of microorganisms after birth in conventional conditions.In contrast to prenatal placental transfer of immunoglobulins in infants, newborn piglets obtain protective antibodies after delivery via colostrum uptake (6, 7).Proper colonization of the gastrointestinal tract with microbiota and adequate nutrition are preconditions of thriving piglets in this critical early postnatal period.Choudhury et al. monitored microbiota (16S rRNA gene amplicon sequencing) and transcriptome (RNA sequencing) influenced by customized fibrous feed in piglets from five days after birth until their weaning at 29 days of age.Early feeding accelerated microbiota and transcriptome development to more mature patterns and made piglets more resistant to post-weaning stress, as it was apparent several days after weaning.The small size of minipigs is convenient regarding housing and manipulation with animals.Goettingen minipigs belong to the most frequently used small pig strains in experimental work (8).Hammer et al. assessed the SLA gene diversity in Goettingen Minipigs in combination with comparative metadata analysis.SLA class I (SLA-1, SLA-2, SLA-3) and class II (DRB1, DQB1, DQA) genes were characterized by PCR-based lowresolution (Lr) haplotyping.Goettingen Minipigs share only six SLA class I and two SLA class II haplotypes with commercial pig lines.Despite the limited number of SLA class I haplotypes, the high genotype diversity being observed necessitates a pre-experimental SLA background assessment of Goettingen Minipigs in regenerative medicine, allotransplantation, and xenograft research.Pernold et al. compared reactivity of peripheral blood mononuclear cells (PMBCs) between humans and Goettingen minipigs, Frontiers in Immunology frontiersin.org01
Šplı́chalová et al. (Mon,) studied this question.
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