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Abstract The prognostic significance of measurable residual disease (MRD) in guiding allogeneic hematopoietic cell transplantation (Allo-HCT) in acute myeloid leukemia (AML) with RUNX1::RUNX1T1 fusion in first complete remission (CR1) requires further elucidation. This retrospective study analyzed 246 patients diagnosed AML with RUNX1::RUNX1T1 fusion to evaluate the prognostic impact of MRD following the second consolidation therapy and the effectiveness of Allo-HCT after achieving CR1. Our findings indicated that 64/246 patients (26%) had a MRD reduction less than 3-log post-second consolidation therapy and it is an independent adverse factor for both CIR (HR = 6.93, P P P P = 0.002) for patients with MRD reduction less than 3-log in univariate time-dependent analyses and was an favorable factor for survival in multivariate model adjusted for MRD and KIT mutation (DFS: HR = 0.21, P P = 0.002) without increasing NRM (HR = 0.85, P = 0.75). In multistate model, the 5-year predicted probability of remaining in CR without undergoing Allo-HCT is significantly lower for patients with MRD reduction less than 3-log compared with those achieved MRD reduction ≥ 3-log (5.2% vs. 50.0%). These findings support MRD-directed Allo-HCT to exert a substantial influence on outcomes for AML patients with RUNX1::RUNX1T1 fusion. These results advocate for the incorporation of MRD status in the criteria for transplantation eligibility to enhance survival rates.
Hou et al. (Fri,) studied this question.