A novel method: Developing and accessing a herbal microemulgel containing Cedrus deodara (Roxb.) G. Don extract for its in vitro anti-inflammatory effects

The aim of this research is to create an innovative formulation, which poses unique challenges.Researchers in this study are particularly interested in exploring the potential of natural bioactive compounds.Various plant extracts have demonstrated therapeutic effects.Cedrus deodara (Roxb.)G. Don, is indigenous to North India, Pakistan, Afghanistan, Tibet, and Nepal.It is rich in various bioactive elements like deodarin, cedodarin, taxifolin, myrcene, iso-pimpillin, -pinene, -pinene, cedrin, deodarone, sesquiterpenes, cedrinoside, dihydromyricetin, matairesinol, and atlantone.Traditionally, people have used it to address a wide range of health concerns, including inflammation, ulcers, pain management, blood sugar control, infections, sleep issues, skin conditions, blood disorders, cell death issues, and fever.Recent investigations, both in laboratory settings and within living organisms, have underscored its anti-inflammatory and painrelieving characteristics.The intended study seeks to formulate and evaluate an herbal microemulgel incorporating an extract from C. deodara to investigate it is in vitro anti-inflammatory potential.The extraction process involved the use of a hydroalcoholic solvent on C. deodara heartwood, followed by an analysis of the extract's phytochemical composition.Subsequently, four formulations of the herbal microemulgel were prepared for further examination and evaluated for various parameters including pH, spreadability, viscosity, consistency, appearance, color and washability.The maximum release of C. deodara microemulgel was 98% at 48 h which indicated that C. deodara microemulgel has good topical release properties.C. deodara microemulsion gel showed 89.89% drug content.The study evaluated the in vitro anti-inflammatory effects of both the C. deodara extract and the formulated microemulgel using HRBC membrane stabilization assay and protein denaturation assay.The findings suggest that the newly developed herbal microemulgel containing C. deodara extract holds potential for future applications in combating inflammation.