Levels of C-Reactive Proteins in Cva Patients and Its Correlation With Lipid Parameters

Stroke,a leading cause of mortality and morbidity globally,results from sudden brain cell death due to inadequate blood flow.Each year,approximately 20 million people experience a stroke,with developing countries accounting for 85% of stroke-related deaths. High-sensitivity C-reactive protein (hs-CRP), a marker of low-grade vascular inflammation, predicts the risk of first ischemic stroke.This study aims to estimate serum CRP levels in patients with cerebrovascular accidents (CVA) and compare them with healthy controls.It also examines the difference in serum CRP levels between hemorrhagic and ischemic strokes.A case-control study was conducted at Maulana Azad Medical College, New Delhi, including 60 acute stroke patients and 60 age- and sex-matched healthy controls. Exclusion criteria involved known cardiac emboli sources,past vascular diseases,active infections,and specific medical conditions.Serum CRP and lipid profiles were measured using standard enzymatic methods, and data were analyzed using SPSS version 20. Stroke patients exhibited significantly higher serum CRP levels (6.56 ± 2.59 mg/l) compared to controls (1.86 ± 0.82 mg/l,p < 0.001).Additionally,lipid parameters (TC,TG,LDL,VLDL) were elevated in stroke patients.Ischemic stroke patients had higher CRP levels (8.16 ± 2.08 mg/l) than hemorrhagic stroke patients (4.18 ± 2.41 mg/l,p < 0.001).Elevated serum CRP levels are significantly associated with cerebrovascular accidents, particularly ischemic strokes. hs-CRP serves as a valuable predictive marker for stroke risk, highlighting the role of inflammation in stroke pathophysiology. Further research is essential to explore the clinical applications of CRP measurements in stroke management and prevention.