Focal pulsed field ablation for complex atrial tachycardia achieved 100% acute procedural success, with 44.1% of patients experiencing recurrence after a mean follow-up of 341 days.
Observational (n=34)
No
Does focal pulsed field ablation provide safe and effective treatment for patients with complex atrial tachycardia?
Focal pulsed field ablation is a safe and feasible option for complex atrial tachycardia, achieving 100% acute success, though long-term recurrence remains notable.
BACKGROUND: Pulsed field ablation (PFA) has become increasingly important in the treatment of cardiac arrhythmias. In addition to single-shot devices mainly used for pulmonary vein isolation, focal PFA may provide a treatment option that increases the versatility of the technique. OBJECTIVE: The purpose of this study was to provide data on feasibility, safety, and long-term outcome of focal PFA for ablation of complex atrial tachycardia (AT). METHODS: All consecutive patients (n = 34) with complex AT treated at our department between 2022 and 2023 with a focal PFA system (CENTAURI™, Galvanize Therapeutics) were included. The majority of patients (32/34) previously had undergone at least 1 radiofrequency ablation. Established contact force-sensing catheters were used for PFA application in combination with a PFA generator. Pulsed electric field trains were conducted in a R-wave triggered manner. RESULTS: Acute procedural success was accomplished in all patients. PFA included creation of 51 linear lesions and (re)isolation of 12 pulmonary veins. Mean procedural duration was 102.7 ± 30.3 minutes, with left atrial dwell time of 75.0 ± 24.7 minutes. Mean fluoroscopy duration was 8.7 ± 5.3 minutes. No complications occurred. After mean follow-up of 340.9 ± 130.1 days, recurrence of any AT occurred in 15 patients (44.1%). During 9 reablations, 3 gaps in previously created linear lesions were detected; the majority of recurrences (n = 6) were not related to previous PFA lesion creation. CONCLUSION: Focal PFA of complex AT substrates was safe and efficient. Acute procedural success was 100%. After 1 year, the majority of patients were in sinus rhythm. A minority of recurrences was caused by insufficient PFA lesion creation.
Erhard et al. (Tue,) conducted a observational in Complex atrial tachycardia (n=34). Focal pulsed field ablation (CENTAURI) was evaluated on Acute procedural success. Focal pulsed field ablation for complex atrial tachycardia achieved 100% acute procedural success, with 44.1% of patients experiencing recurrence after a mean follow-up of 341 days.