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Abstract The synthesis of substituted 3‐oxo‐pyrimido1,2‐ b indazoles from 3‐aminoindazoles and ketones has been established. It involves one molecule of 3‐aminoindazoles and two molecules of ketones via a 3+2+1 three‐component annulation process. 3‐Oxo‐pyrimido1,2‐bindazoles exhibit strong yellow fluorescence in various solvents. A wide range of products have anti‐oxidant activities. Cytotoxicity studies indicate that compounds 3 a , 3 aa and 3 ab have obvious effects on both HCT116 and A549 cancer cell lines.
Zhang et al. (Sat,) studied this question.