Migraine: pathophysiology, evaluation, and management

Migraine is a common long term primary headache disorder characterized by recurrent bouts of moderate to severe headaches. Migraine attacks can be debilitating with significant functional disability. Research has identified key mechanisms and triggers in migraine pathophysiology which has enabled development of promising new targets in migraine management. There are many therapeutic options in the treatment of migraine and the choice of treatment should be geared to the patient needs and co-morbidities.