Randomized Trial of Nitrate-Replete Beetroot Juice on Blood Pressure in Hypertensive Adults with ADPKD

Reduced circulating levels of nitric oxide metabolites are hypothesized, in part, to drive hypertension in autosomal dominant polycystic kidney disease (ADPKD).1 Beetroot juice (BRJ), a rich dietary source of nitrate, increases nitric oxide metabolites via the entero-salivary nitrate-nitrite-NO pathway, and lowers blood pressure (BP).2 In the largest randomized controlled trial of 68 hypertensive patients, nitrate-replete BRJ reduced systolic BP by a mean of 9.0 ± 7.8 mm Hg after 4-weeks compared to 0.1 ± 8.0 mm Hg in the nitrate-deplete BRJ group.