Research progress of serum albumin in the field of drug delivery

Abstract As a drug delivery system with wide application potential, serum albumin drug‐carrying nanoparticles have attracted extensive attention in the field of drug delivery in recent years. This review aims to summarize the research progress of serum albumin drug‐loaded nanoparticles in the field of drug delivery. Firstly, the excellent properties of serum albumin as a drug carrier were introduced, several methods of preparing serum albumin nanoparticles were discussed in depth, and their advantages and disadvantages were compared. Then, the design of the nanoparticle albumin drug carrier is discussed, including the control of the size of the nanoparticle, the surface properties and the amount of drug loading, so as to achieve better drug delivery effect. Finally, a series of therapeutic approaches using serum albumin nanoparticles as drug carriers, such as anti‐cancer drug delivery and drug delivery across the blood‐brain barrier, are systematically summarized. In summary, the research of serum albumin drug‐carrying nanoparticles has brought new possibilities and opportunities to the field of drug delivery, and inspired more innovative research and practical applications.