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PurposeTetralogy of Fallot (TOF) is a congenital heart disease, and patients undergo surgical repair early in their lives. The evaluation of TOF patients is continuous through their adulthood. The use of cardiac magnetic resonance imaging (CMR) is vital for the evaluation of TOF patients. We aim to correlate advanced MRI sequences parametric longitudinal relaxation time (T1), extracellular volume (ECV) mapping with cardiac functionality to provide biomarkers for the evaluation of these patients. MethodsA complete CMR examination with the same imaging protocol was conducted in a total of 11 TOF patients and a control group of 25 healthy individuals. A Modified Look-Locker Inversion recovery (MOLLI) sequence was included to acquire the global T1 myocardial relaxation times of the left ventricular (LV) pre and post-contrast administration. Appropriate software (Circle cmr42) was used for the CMR analysis and the calculation of native, post-contrast T1, and ECV maps. A regression analysis was conducted for the correlation between global LV T1 values and right ventricular (RV) functional indices. ResultsStatistically significant results were obtained for RV cardiac index RVCI= −32. 765 + 0. 029 × T1 native; p=0. 003, RV end diastolic volume RVEDV/BSA = −1023. 872 + 0. 902 × T1 native; p=0. 001, and RV end systolic volume RVESV/BSA = −536. 704 + 0. 472 × T1 native; p=0. 011. ConclusionsWe further support the diagnostic importance of T1 mapping as a structural imaging tool in CMR. In addition to the well-known affected RV function in TOF patients, the LV structure is also impaired as there is a strong correlation between LV T1 mapping and RV function, evoking that the heart operates as an entity.
Broumpoulis et al. (Thu,) studied this question.
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